Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, nonhodgkins lymphoma, and multiple myeloma or kidney disease. Multiple myeloma, waldenstroms evil cousin, is characterized by malignant proliferation of plasma cells. This light chain is called serum beta 2 microglobulin because it was initially discovered as a serum protein before its role as part of the class i antigen was elucidated. Beta2 microglobulin b2m is a protein that is found on the surface of almost all cells in the body and is shed by cells into the blood, particularly by b lymphocytes and tumor cells. Patients may present with bone pain or with symptoms that are often nonspecific, such as nausea. In serum or plasma samples, the reference range is 03 gml. A 61yearold man who had 40 months history of recurrent multiple myeloma presented a right testicular mass. Sep 05, 2014 the reference range of beta 2 microglobulin in urine samples is 00.
Beta2microglobulin is a serum maker of tumor burden in hematologic malignancies. It is recommended that each laboratory establish its own normal and pathological ranges of urine levels. Pretreatment levels of serum beta 2 microglobulin were. Stage i early disease low production of monoclonal protein and. The b2m test can be used as a tumor marker for some people with blood cell cancers multiple myeloma, lymphoma to give information about their likely prognosis. Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood. Interpretation depends on the specific clinical indication and context.
Beta 2 microglobulin b2m is a protein shed by cells into the blood, including tumor cells. Multiple myeloma early detection, diagnosis, and staging. Celulas plasmaticas, mieloma multiple, sistema nervioso central. Beta 2microglobulin beta 2m is a small membrane protein 11,800 dalton associated with the heavy chains of class i major histocompatibility complex proteins and is, therefore, on the surface of all nucleated cells. Guillermo conte l 1,7, gaston figueroa m 1, vivianne lois v 2, maria elena cabrera c 3, alvaro leon r 4, hernan garcia l 5, hernan rojas r 6. Multiple myeloma, multiple myeloma, laboratory diagnosis, mgus, multiple myeloma smoldering. Pretreatment values were useful in confirming tumor mass grade, and marked reductions following chemotherapy correlated. Mieloma multiple hematologia y oncologia manual msd version. Beta 2microglobulin beta 2m is a low molecular weight protein of importance in the evaluation of the reabsorptive capacity of the proximal kidney tubule.
The specific gene abnormalities cytogenetics of the cancer. As of 2011 update, a patient with a level 4 mgl has a median survival of only 12 months. Mortality rate records are the only data available in. Abstract multiple myeloma is a haematological malignancy with the common denominator in the production of m protein, and a variety of clinical presentation that throughout history has required adjustments to the. Caracteristicas clinicas y sobrevida guillermo conte l1,7, gaston figueroa m1, vivianne lois v2, maria elena cabrera c3, alvaro leon r4, hernan garcia l5, hernan rojas r6. The small size allows beta 2m to pass through the glomerular membrane, but it is almost completely reabsorbed in the proximal tubules. Abstract multiple myeloma is a monoclonal gammopathy with proliferation of plasma cells. Beta 2 microglobulin is a low molecular weight protein found on the surface of all nucleated cells. Mieloma multiplo hematologia e oncologia manuais msd. Its form of presentation is hypercalcemia, osteolytic lesions, anemia and renal failure. Abstract multiple myeloma is a haematological malignancy with the common denominator in.
Clinical features and survival of chilean patients with multiple myeloma. The increased levels of serum beta 2 microglobulin in patients with multiple myeloma have been associated with a poor prognosis. Although this protein itself doesnt cause problems, it can be a useful indicator of a patients prognosis. In multiple myeloma, beta 2 microglobulin is a powerful prognostic factor and serum beta 2microglobulin values beta 2 microglobulin levels in 100 patients with myeloma it was reported that the median survival of patients with values 4 mcgml was 12 months. The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia or amyloidosis. Serum beta 2 microglobulin levels b2m were evaluated before and during chemotherapy in 97 previously untreated. Proteina normal do sangue medida regularmente como parte dos testes bioquimicos. Mieloma multiple tratamiento free download pdf ebook. As of 2011 update, a patient with a level microglobulin test. Beta 2 microglobulin this is another protein made by the myeloma cells. Prognostic importance of beta2microglobulin in multiple. Mieloma multiple etiologia, fisiopatologia, sintomas, signos, diagnostico y. Clinical features and survival of chilean patients with multiple myeloma background. The involvement of the central nervous system is rare.
The increased levels of serum beta 2 microglobulin. Serum beta 2 microglobulin levels b2m were evaluated before and during chemotherapy in 97 previously untreated patients with multiple myeloma. Mieloma multiple en una paciente leonardo baldovinosnaranjo1. Definition beta 2 microglobulin is a protein found on the surface of many cells. Multiple myeloma early detection, diagnosis, and staging 1. Pretreatment values were useful in confirming tumor mass grade, and marked reductions following chemotherapy correlated well with the onset of remission.